GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs11014306 | 1 | rs6482455 | chr10:25200457 | PRTFDC1 | chr10:25137554-25241533:- | 0.27 | 3.62 | 0.000329 | Metabolite levels (Pyroglutamine) |
| THCA | cis | rs11825709 | 1 | rs6483278 | chr11:93640502 | HEPHL1 | chr11:93754378-93847374:+ | -0.49 | -4.27 | 2.4E-5 | Obesity-related traits |
| THCA | cis | rs7118648 | 1 | rs6483501 | chr11:96108061 | CCDC82 | chr11:96085930-96123083:- | -0.24 | -3.81 | 0.000157 | Parkinson's disease |
| THCA | cis | rs712022 | 1 | rs6483880 | chr11:22852740 | SVIP | chr11:22843600-22851382:- | 0.27 | 6.45 | 2.71E-10 | Dialysis-related mortality |
| THCA | cis | rs4237643 | 1 | rs6485438 | chr11:43686618 | HSD17B12 | chr11:43702143-43878160:+ | -0.7 | -14.66 | 1.94E-40 | Forced vital capacity |
| THCA | cis | rs4237643 | 1 | rs6485443 | chr11:43696316 | HSD17B12 | chr11:43702143-43878160:+ | 0.72 | 15.11 | 1.83E-42 | Forced vital capacity |
| THCA | cis | rs7951870 | 1 | rs6485682 | chr11:46446264 | PACSIN3 | chr11:47199085-47207958:- | -0.16 | -3.64 | 0.000299 | Schizophrenia |
| THCA | cis | rs747782 | 1 | rs6485784 | chr11:47832260 | FAM180B | chr11:47608245-47610746:+ | 0.2 | 3.39 | 0.000753 | Intraocular pressure |
| THCA | cis | rs747782 | 1 | rs6485788 | chr11:47873883 | FAM180B | chr11:47608245-47610746:+ | -0.2 | -3.39 | 0.000752 | Intraocular pressure |
| THCA | cis | rs7937890 | 1 | rs6486190 | chr11:14401216 | RRAS2 | chr11:14299467-14380729:- | -0.17 | -4.19 | 3.38E-5 | Mitochondrial DNA levels |
| THCA | cis | rs6487679 | 1 | rs6487679 | chr12:9371332 | DDX12 | chr12:9570288-9600768:- | 0.16 | 3.56 | 0.000403 | Non-alcoholic fatty liver disease histology (AST) |
| THCA | cis | rs6487679 | 1 | rs6487679 | chr12:9371332 | LOC144571 | chr12:9217773-9220651:+ | 0.14 | 3.47 | 0.000562 | Non-alcoholic fatty liver disease histology (AST) |
| THCA | cis | rs6487679 | 1 | rs6487679 | chr12:9371332 | LOC642846 | chr12:9436253-9466684:+ | 0.42 | 8.18 | 2.59E-15 | Non-alcoholic fatty liver disease histology (AST) |
| THCA | cis | rs11051970 | 1 | rs6488051 | chr12:32532733 | DENND5B | chr12:31535157-31743952:- | -0.17 | -3.4 | 0.000739 | Response to tocilizumab in rheumatoid arthritis |
| THCA | cis | rs11051970 | 1 | rs6488051 | chr12:32532733 | FGD4 | chr12:32638906-32798982:+ | -0.29 | -7.59 | 1.68E-13 | Response to tocilizumab in rheumatoid arthritis |